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[macsnafu]

Call me nuts, but I'd like to see a sequencer/tracker program that combines the various ways sound can be created on a computer: midi with the built-in midi sounds, mod tracking with samples, softsynths, digital audio recording, maybe even the old FM/Adlib sounds all in one program, with midi input (for playing/recording) and a common sequencing/tracking interface.  Effects and output to WAV/MP3 would be nice, too. 

I know there are various programs that can do some of this, like Buzz, which does softsynths and mod tracking/sampling, but I'm not aware of anything that does it all.

[Saga Musix]

It's not difficult to combine it all, mostly because many DAWs support plugins these days: There are several plugins available which can output MIDI to any given MIDI device (I have written such a plugin for OpenMPT), so it can also output sound to the crappy built-in GM Synth in windows. Of course you can also play samples in OpenMPT and use other softsynth / effect plugins. I am not aware of any plugin that specifically emulates the AdLib chip, but there are plugins like VOPM that emulate very similar chips, so you could use that. All of this would be possible in other trackers as well, such as Renoise.