The Konami VRC7 chip was the first chip ever to incorporate 16-bit-like sound to an 8-bit game. An example would be "Lagrange Point", which was released in Japan Only. By design the VRC7 adds on 6 channels to the five already provided by the NES/Famicom, due in part to more-advanced bank switching than the predecessor, the Konami VRC6. And quite frankly, it's not your usual bleeps and bloops that most of the other games have been making--the instruments sound good, although it's still far from 16-bit as it gets. ("Lagrange Point" does use the DPCM channel on the NES/Famicom for bass drums though.)
For anyone who hasn't "heard" it yet, you could go to Zophar's Domain and listen to an NSF of that game.
Does anyone have any samples that were taken from a VRC7-enabled game?